Table 4 Selected changes in gene expression in commonly amplified or deleted regions of the genome for all biliary tract cancer specimens
Chromosomal Location | % Amplified (+) or Deleted (-) | Fold Change | Gene Title | Gene Symbol | Functional Properties |
|---|---|---|---|---|---|
chr7p11 | +42% | 6.5 | IGF-II mRNA-binding protein 3 | IMP-3 | RNA processing |
chr7p13-p12 | +45% | 3.6 | insulin-like growth factor binding protein 3 | IGFBP3 | Regulation of cell growth |
chr5p15.33 | +42% | 3.5 | thyroid hormone receptor interactor 13 | TRIP13 | Regulation of transcription |
chr20q13.32 | +45% | 3.5 | RAE1 RNA export 1 homolog | RAE1 | mRNA-nucleus export |
chr7p21.1 | +48% | 3.2 | basic leucine zipper and W2 domains 2 | BZW2 | Translation initiation factor |
chr7q22.1 | +42% | 3.0 | origin recognition complex, subunit 5-like | ORC5L | DNA replication initiation |
chr20q13.3 | +42% | 2.7 | ribosomal protein S21 | RPS21 | Protien biosysthesis |
chr7p15 | +42% | 2.6 | oxysterol binding protein-like 3 | OSBPL3 | Steroid metabolism |
chr7p15-p13 | +42% | 2.5 | v-ral simian leukemia viral oncogene homolog A | RALA | GTPase mediated signal transduction |
chr20q13.2 | +48% | -6.9 | docking protein 5 | DOK5 | Insulin receptor binding |
chr7q11.2 | +42% | -7.8 | CD36 antigen | CD36 | Lipid metabolism |
chr7q21.1 | +42% | -7.9 | ATP-binding cassette, sub-family B, member 1 | ABCB1 | Cell surface transport |
chr7p21 | +45% | -9.1 | interleukin 6 | IL6 | Acute phase response |
chr20q11.23 | +42% | -10.0 | myosin, light polypeptide 9, regulatory | MYL9 | Regulation of muscle contraction |
chr7q31-q32 | +42% | -10.9 | solute carrier family 13, member 1 | SLC13A1 | Ion transport |
chr20q13.13 | +45% | -14.7 | prostaglandin I2 synthase | PTGIS | Prostaglandin biosynthesis |
chr7q31 | +42% | -38.1 | solute carrier family 26, member 3 | SLC26A3 | Transcription factor activity |
chr6q22.1 | -55% | -46.2 | phospholamban | PLN | Calcium ion transport |
chr9q22 | -42% | -41.0 | osteoglycin | OGN | Growth factor activity |
chr6q24-q25 | -58% | -19.2 | A kinase anchor protein 12 | AKAP12 | Signal transduction |
chr14q24.3 | -42% | -17.1 | v-fos FBJ murine osteosarcoma viral oncogene homolog | FOS | DNA methylation |
chr14q32.1 | -45% | -13.6 | fibulin 5 | FBLN5 | Cell-matrix adhesion |
chr3p26-p25 | -45% | -10.0 | inositol 1,4,5-triphosphate receptor, type 1 | ITPR1 | Cation transport |
chr3p13 | -52% | -9.2 | PDZ domain containing RING finger 3 | PDZRN3 | Protein ubiquitination |
chr3p21.1 | -58% | -8.9 | TU3A protein | TU3A | Regulation of cell growth |
chr14q32.1 | -48% | -8.5 | serine proteinase inhibitor, clade A, member 5 | SERPINA5 | Endopeptidase inhibitor |
chr3p22-p21.3 | -58% | -8.5 | C-type lectin domain family 3, member B | CLEC3B | Skeletal development |
chr9p13.2-p13.1 | -42% | -8.3 | tropomyosin 2 | TPM2 | Muscle development |
chr14q32 | -48% | -8.1 | delta-like 1 homolog | DLK1 | Calcium ion binding |
chr6q27 | -58% | -6.5 | ribosomal protein S6 kinase, 90 kDa, polypeptide 2 | RPS6KA2 | Amino acid phosphorylation |
chr6q24-q25 | -52% | -6.2 | pleiomorphic adenoma gene-like 1 | PLAGL1 | Regulation of transcription |
chr9p13-p12 | -42% | -5.8 | reversion-inducing-cysteine-rich protein with kazal motifs | RECK | Cell cycle regulation |
chr3p21.2-p21.1 | -61% | -5.4 | aminomethyltransferase | AMT | Glycine catabolism |
chr6pter-qter | -48% | -5.4 | transcription factor 21 | TCF21 | Regulation of transcription |
chr9q13 | -42% | -5.1 | Kruppel-like factor 9 | KLF9 | Regulation of transcription |
chr6q23 | -48% | -3.8 | serum/glucocorticoid regulated kinase | SGK | Amino acid phosphorylation |
chr3p26-p25 | -45% | -3.6 | inositol 1,4,5-triphosphate receptor, type 1 | ITPR1 | Cell cycle regulation |
chr1p36.13-p36.11 | -55% | -3.2 | neuroblastoma, suppression of tumorigenicity 1 | NBL1 | calcium ion transport |
chr6q22 | -55% | -2.6 | mannosidase, alpha, class 1A, member 1 | MAN1A1 | Carbohydrate metabolism |
chr3p22 | -48% | -2.5 | transforming growth factor, beta receptor II | TGFBR2 | Regulation of cell proliferation |