Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations

Table 3 p-ERK1/2 and PI3-K expression in gallbladder adenocarcinoma as determined by immunohistochemistry.

	Total	pERK1/2 + (%)	P value	PI3-K + (%)	P value
Pathology type*
Adenoma canceration	9	3(33.3)		2(22.2)
Well-differentiated	29	12(41.4)	<0.01	10(34.5)	<0.01
Moderately-differentiated	29	18(62.1)		16(55.2)
Poorly-differentiated	30	25(83.3)		23(76.7)
Mucous adenoma	11	5(45.5)		4(36.4)

*Comparison of adenoma lesions and poorly-differentiated adenocarcinomas, P_pERK = 0.08, P_PI3-K = 0.05, comparison of the well-differentiated and poorly-differentiated, χ²_pERK = 11.10, P < 0.01; χ²_PI3-K = 10.65, P < 0.01.

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