Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines

Table 1 Sensitivity of solid tumor cells lines to gemcitabine and paclitaxel

Cell line/Exposure	H460	H520	H838
IC-50 Gemcitabine (nM)
24 h	6.7	1541.1	72.8
IC-50 Paclitaxel (nM)
24 h	178.0	241.6	7.2

The IC-50 is defined as the concentration that causes 50% inhibition of cell growth after exposure to either gemcitabine 24 h or paclitaxel 24 h. Growth inhibition was determined using a direct cell count and the fraction affected was averaged from three independent experiments with six replicates to calculate the IC-50 using CalcuSyn (v 2.0, Biosoft).

ISSN: 1756-9966