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Table 1 Sensitivity of solid tumor cells lines to gemcitabine and paclitaxel

From: Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines

Cell line/Exposure H460 H520 H838
IC-50 Gemcitabine (nM)
24 h 6.7 1541.1 72.8
IC-50 Paclitaxel (nM)
24 h 178.0 241.6 7.2
  1. The IC-50 is defined as the concentration that causes 50% inhibition of cell growth after exposure to either gemcitabine 24 h or paclitaxel 24 h. Growth inhibition was determined using a direct cell count and the fraction affected was averaged from three independent experiments with six replicates to calculate the IC-50 using CalcuSyn (v 2.0, Biosoft).