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Table 2 Combination index of solid tumor cell lines for gemcitabine and paclitaxel

From: Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines

Exposure/Cell line H460 H520 H838
PAC 24 h > GEM 24 h 0.58 ± 0.84 0.006 ± 0.010 0.63 ± 0.03
Predicted Interaction Synergistic Highly Synergistic Synergistic
GEM 24 h > PAC 24 h 0.60 ± 0.91 0.34 ± 0.41 0.50 ± 0.57
Predicted Interaction Synergistic Synergistic Synergistic
  1. Mean (± standard deviation) CI values after exposure to paclitaxel for 24 hours followed by gemcitabine for 24 hours or gemcitabine for 24 hours followed by paclitaxel 24 hours. The mean CI values represent the average of the CI at the fraction affected of 0.50, 0.75, 0.90 and 0.95. Cells were seeded in 6-well flat bottom plates in duplicate at 5 separate concentrations of constant ratio based on the ratio of the observed IC-50 values. Three independent counts were conducted for each well with a total of six replicates and the CI was determined using an algebraic estimation algorithm with the aide of CalcuSyn (v 2.0, Biosoft).