Exposure/Cell line | H460 | H520 | H838 |
|---|
PAC 24 h > GEM 24 h | 0.58 ± 0.84 | 0.006 ± 0.010 | 0.63 ± 0.03 |
Predicted Interaction | Synergistic | Highly Synergistic | Synergistic |
GEM 24 h > PAC 24 h | 0.60 ± 0.91 | 0.34 ± 0.41 | 0.50 ± 0.57 |
Predicted Interaction | Synergistic | Synergistic | Synergistic |
- Mean (± standard deviation) CI values after exposure to paclitaxel for 24 hours followed by gemcitabine for 24 hours or gemcitabine for 24 hours followed by paclitaxel 24 hours. The mean CI values represent the average of the CI at the fraction affected of 0.50, 0.75, 0.90 and 0.95. Cells were seeded in 6-well flat bottom plates in duplicate at 5 separate concentrations of constant ratio based on the ratio of the observed IC-50 values. Three independent counts were conducted for each well with a total of six replicates and the CI was determined using an algebraic estimation algorithm with the aide of CalcuSyn (v 2.0, Biosoft).
