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Table 3 Effects of paclitaxel on deoxycytdine kinase and cytidine deaminase activity in solid tumor cell lines

From: Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines

Exposure/Cell line H460 H520 H838
Control
%G0 + G1 66 ± 1.2 62 ± 2.1 80 ± 7.5
%G2 + M 8.0 ± 1.4 13.2 ± 1.0 4.8 ± 2.4
%S 26 ± 1.7 25 ± 1.3 15 ± 5.1
% Apoptosis 7.5 ± 1.7 3.2 ± 0.6 9.7 ± 7.2
PAC 24 h > GEM 24 h
%G0 + G1 17 ± 11 36 ± 6.4 23 ± 6.0
%G2 + M 25 ± 7.8 44 ± 6.4a 15 ± 4.7
%S 58 ± 3.2 20 ± 2.3 41 ± 1.0
% Apoptosis 8.6 ± 5.1 2.1 ± 1.4 4.6 ± 1.0
GEM 24 h > PAC 24 h
%G0 + G1 13 ± 6.0 62 ± 4.9a 23 ± 10.3
%G2 + M 30 ± 1.7 9.7 ± 1.6 9.8 ± 8.0
%S 56 ± 7.7 28.8 ± 3.5 43 ± 1.6
% Apoptosis 7.0 ± 4.9 3.4 ± 2.2 0.87 ± 0.05a
  1. Mean (± standard deviation) percentage of cells in each phase of the cell cycle after exposure to vehicle control or sequential paclitaxel → gemcitabine or gemcitabine → paclitaxel at 24 hours intervals. The mean represents three independent experiments with each experiment conducted in at least triplicate.
  2. a P < 0.05, paclitaxel vs. vehicle-control treated cells