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Table 2 Non-Randomized Controlled Clinical VAE Studies on Breast and Gynaecological Cancer: Quality Assessment

From: Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research

Author, Year Quality Criteria Fulfilled in StudiesI Participants ARII Design/control for confounding
  A) B) C) D) E) F) G) H) I) J) K)    
Grossarth 2008c [49] (+) + - (-) + + + (+) + + - 200 5% Prospective pair-matching
Grossarth 2008d [49] (+) + - (-) + (-) + (+) + + - 282 27% Prospective pair-matching
Loewe-Mesch 2008 [64] - - - (-) + (-) + + (+) + - 82 20% Self-selected treatment allocation, no adjustment
Grossarth 2007d [50] (+) + - (-) + (-) + (+) + + - 198 24% Prospective pair-matching
Grossarth 2007e [50] (+) + - (-) + + + (+) + + - 132 6% Prospective pair-matching
Grossarth 2007f [51] (+) + - (-) + + + (+) + + - 212 4% Prospective pair-matching
Grossarth 2007g [51] (+) + - (-) + + + (+) + + - 140 6% Prospective pair-matching
Grossarth 2006b [52, 53] (+) + - (-) + (-) + (+) + + - 210 20% Prospective pair-matching
Büssing 2005 [65] (-) - - (-) + + (+) (+) (+) + + 105 7% Comparison of two different hospitals. Pair-matching for analysis
Grossarth 2001c [59] (+) + - (-) + + + - + + - 792 4% Prospective pair-matching
Salzer 1987 [66] (+) - - (-) + - + - - (+) - 155 not shown Alternating treatment allocation
Fellmer 1966 [67] - - - (-) + - + + - - - 924 15% Treatment allocation by neutral attending physician
Majewski 1963 [68] (+) - - (-) + - + - - - - III not shown (15%)IV Alternating treatment allocation
Retrolective pharmaco-epidemiological cohort studies
Beuth 2008 [69] - (+) - - (-) - (+) (-) (+) (+) + 681 V Multivariate adjustment only for one main outcome ("complaints")
Bock 2004 [70] - (+) - - (-) - (+) + (+) (+) + 1442 V Multivariate adjustment
Schumacher 2003 [71, 72] - (+) - - (-) - (+) + (+) (+) + 689 V Propensity score adjustment
  1. I–II Abbreviations as in Table 1.
  2. III Number of study patients not indicated; mistletoe group included 155 patients.
  3. IV Numbers given only for mistletoe group.
  4. V Not applicable for retrolective studies.