Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma

Table 2 Association of Lamin A/C immunostaining with clinicopathological parameters in 126 cases of primary GC

Clinicopathological variable	Cases (n = 126)	Lamin A/C		p-value
		positive (%)	negative (%)
		n = 70	n = 56
Gender				0.410
male	88	51 (58.0)	37 (42.0)
female	38	19 (50.0)	19 (50.0)
Age (years) ^a				0.905
< 56	60	33 (55.0)	27 (45.0)
≥ 56	66	37 (56.1)	29 (43.9)
Tumour size (cm) ^a				0.902
< 5	78	43 (55.1)	35 (44.9)
≥ 5	48	27 (56.3)	21 (43.7)
Depth of invasion				0.870
T1	9	6 (66.7)	3 (33.3)
T2	22	12 (54.5)	10 (45.5)
T3	75	42(56.0)	33 (44.0)
T4	20	10 (50.0)	10 (50.0)
Lymph node metastasis ^b				0.550
N₀	42	23 (54.8)	19 (45.2)
N₁	36	22 (61.1)	14 (38.9)
N₂	38	18 (47.4)	20(52.6)
N₃	10	7(70.0)	3 (30.0)
Distant metastasis				0.659
M0	101	55 (54.5)	40 (45.5)
M1	25	15(60.0)	10 (40.0)
Staging				0.894
I	17	10 (58.8)	7 (41.2)
II	27	14 (51.9)	13 (48.1)
III	47	25 (53.2)	22 (46.8)
IV	35	21 (60.0)	14 (40.0)
Differentiation				0.034^c
well	19	15(78.9)	4 (21.1)
moderate	20	13(65.0)	7 (35.0)
poor	67	35(51.6)	32 (48.4)
undifferentiated	20	7 (35.0)	13 (65.0)

^agrouping of age and tumour size was performed according to median.
^b grouping of staging and lymph node metastasis was performed according to UICC classification (TNM 1997).
^cstatistical significance (p < 0.05)

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