Figure 4

Inhibition of Survivin mRNA and protein expression in SW480 and LoVo cells. The cancer cells were treated with ZD55-Sur-EGFP, ZD55-EGFP, AD-Sur-EGFP and AD-EGFP respectively at MOI of 10. a: AD-EGFP group b: ZD55-EGFP group c: AD-Sur-EGFP group d: ZD55-Sur-EGFP group. (A) RT-PCR showed significant reduction of Survivin mRNA in ZD55-Sur-EGFP and AD55-Sur-EGFP treated cells. (B) Survivin protein levels in above mentioned groups were consistent with mRNA expression by Westen blot, and XIAP protein expression was not affected. **P < 0.0001, *P < 0.05