Figure 9
Antitumor effects of oncolytic virus mediated Survivin RNAi in nude mice xenograft tumor model. 4-week-old female BALBC/C nude mice were injected subcutaneously with SW480 cells and then with adenoviruses injected through the tail vein. After 60 days, the mice were sarcrificed and the tumors were harvested. A: AD-EGFP group B: ZD55-Sur-EGFP group C: ZD55-EGFP group D: AD-Sur-EGFP group E: PBS group (a) Representative tumor formations, 60 days after injection. (b) Tumor volume after 60 days of injection was quantitatively represented. Data were expressed as mean ± SD. *P < 0.01 vs other groups (c) Western blotting of proteins from xenograft tumors. The result was consistent with that on cell level.