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Table 2 Correlation between gene expression and GEM efficacy in patients with pancreatic cancer receiving GEM monotherapy.

From: Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancer

   GEM efficacy  
Gene Expression*   Effective§ Non-effective P-value
hENT1 High 4 9 >0.9999
  Low 8 14  
hENT2 High 6 9 0.5374
  Low 6 14  
dCK High 8 7 0.0398
  Low 4 16  
DCD High 3 9 0.4765
  Low 9 14  
CDA High 4 9 >0.9999
  Low 8 14  
5'-NT High 4 12 0.2882
  Low 8 11  
RRM1 High 4 8 >0.9999
  Low 8 15  
RRM2 High 4 8 >0.9999
  Low 8 15  
  1. GEM, gemcitabine
  2. *Gene expression was determined as high or low based on mean values of 35 EUS-FNA samples.
  3. §Effective, partial response by imaging study or stable disease by imaging study with 50% or more decrease in tumor markers compared to pretreatment value
  4. P, examined by chi-squared test (Fisher's exact test)