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Table 2 Correlation between gene expression and GEM efficacy in patients with pancreatic cancer receiving GEM monotherapy.

From: Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancer

  

GEM efficacy

 

Gene Expression*

 

Effective§

Non-effective

P¶-value

hENT1

High

4

9

>0.9999

 

Low

8

14

 

hENT2

High

6

9

0.5374

 

Low

6

14

 

dCK

High

8

7

0.0398

 

Low

4

16

 

DCD

High

3

9

0.4765

 

Low

9

14

 

CDA

High

4

9

>0.9999

 

Low

8

14

 

5'-NT

High

4

12

0.2882

 

Low

8

11

 

RRM1

High

4

8

>0.9999

 

Low

8

15

 

RRM2

High

4

8

>0.9999

 

Low

8

15

 
  1. GEM, gemcitabine
  2. *Gene expression was determined as high or low based on mean values of 35 EUS-FNA samples.
  3. §Effective, partial response by imaging study or stable disease by imaging study with 50% or more decrease in tumor markers compared to pretreatment value
  4. ¶P, examined by chi-squared test (Fisher's exact test)