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Table 2 Selenite-induced loss of mitochondrial membrane potential and effects of inhibition of apoptosis signalling enzymes

From: Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure

  Epithelioid cells Sarcomatoid cells
Inhibitor Loss of δΦ m after selenite treatment a Statistical significance vs. no selenite b Statistical significance vs. selenite only c Loss of δΦ m after selenite treatment a Statistical significance vs. no selenite b Statistical significance vs. selenite only c
Positive control 2.89 (± 0.68)    1.28 (± 0.18)   
Selenite 3.41 (± 0.57) p < 0.01   3.30 (± 0.24) p < 0.001  
JNK 0,94 (± 0.06)    1.05 (± 0.05)   
JNK + selenite 3,96 (± 0.58) p < 0.001 ns 3.74 (± 0.25) p < 0.001 ns
p38 0.99 (± 0.04)    0.88 (± 0.03)   
p38 + selenite 4.06 (± 0.63) p < 0.001 ns 4.15 (± 0.52) p < 0.001 ns
p53 0.74 (± 0.05)    0.92 (± 0.03)   
p53 + selenite 2.62 (± 0.57) p < 0.05 ns 3.59 (± 0.52) p < 0.001 ns
Cathepsin B 1.27 (± 0.12)    1.46 (± 0.10)   
Cathepsin B + selenite 5.68 (± 0.70) p < 0.001 ns 6.27 (± 0.75) p < 0.001 p < 0.01
Cathepsin D, E 0.93 (± 0.06)    0.90 (± 0.03)   
Cathepsin D, E + selenite 3.95 (± 0.77) p < 0.001 ns 3.45 (± 0.37) p < 0.001 ns
  1. a: Fold change in JC-1 green fluorescence. Range shows the standard error of the mean (SEM).
  2. b: One-way ANOVA analyses were performed with Bonferroni's multiple comparisons test.
  3. c: One-way ANOVA analyses were performed with Dunnett's post test. ns = not significant.