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Table 1 Pharmacokinetics of imatinib in Balb/C mice in the presence and absence of tariquidar

From: Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice

 

Imatinib alone

Imatinib + Tariquidar

  

Plasma

Mean

SD

Mean

SD

Fold Change

P-value

Cmax (ng/mL)

5,710.5

1,472.3

6,813.2

1,547.9

1.19

-

Tmax

(hr)

0.17

-

0.17

-

-

-

AUC0–24

(hr*ng/mL)

12,167.5

-

26,724.6

-

2.20

0.001

Liver

Mean

SD

Mean

SD

Fold Change

P-value

Cmax

(ng/g)

26,279.7

4,560.2

46,139.1

11,000.6

1.76

-

Tmax

(hr)

0.25

-

0.17

-

-

-

AUC0–24

(hr*ng/g)

68,330.8

-

153,209.2

-

2.24

< 0.00001

Brain

Mean

SD

Mean

SD

Fold Change

P-value

Cmax

(ng/g)

194.7

27.2

417.0

116.6

2.14

-

Tmax

(hr)

2

-

2

-

-

-

AUC0–4

(hr*ng/g)

574.23

-

1,277.7

-

2.23

0.00001