Figure 2
From: Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro
PTL induced BxPC-3 apoptosis. BxPC-3 cells were treated with the indicated concentrations of PTL for 48 hours. (A) The quantification of apoptosis was estimated by Annexin-V/PI-FACS analysis. As apoptotic events Annexin-V-positive cells (right quadrant in the density dot plot) were summarized. (B) DNA Fragmentation Analysis indicated that the cells treated with higher concentrations of PTL showed higher proportions of apoptotic internucleosomal DNA fragmentation. These results revealed that PTL-induced apoptosis in BxPC-3 cells was in a dose-dependent manner. The data was described as mean ± SD (n = 3) and the representative figures are shown.