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Table 1 Sensitivity of Bel-7402/ADMS, Bel-7402/ADML and Bel-7402/ADMV cells to multiple chemotherapy drugs.

From: Comparison of the multi-drug resistant human hepatocellular carcinoma cell line Bel-7402/ADM model established by three methods

Drug

IC50(mg.L-1, x ¯ ± s)

RI

 

Bel-7402

Bel-7402/ADMS

Bel-7402/ADML

Bel-7402/ADMV

RIS

RIL

RIV

ADM

2.09 ± 0.13

26.69 ± 0.46

26.92 ± 0.38

46.93 ± 0.82

12.77

12.88

22.45

CDDP

0.98 ± 0.11

12.92 ± 3.45

13.46 ± 3.00

25.18 ± 3.57

13.18

13.73

25.69

MMC

0.54 ± 0.05

0.57 ± 0.08

0.60 ± 0.08

0.62 ± 0.04

1.06

1.11

1.15

MTX

0.15 ± 0.05

0.17 ± 0.05

0.20 ± 0.06

0.21 ± 0.05

1.13

1.33

1.4

5-FU

119.65 ± 6.46

120.78 ± 4.84

121.60 ± 6.15

123.66 ± 5.00

1.01

1.02

1.03

  1. Note: By least significant difference (LSD) paired-comparison in both ADM and CDDP groups, except Bel-7402/ADML vs. Bel-7402/ADMS (P > 0.05), there is no statistical significance. In other groups of resistant cells, there is a significant difference by paired-comparison. In addition, in MMC, MTX and 5-FU groups, there is no statistical significance by paired-comparison (P > 0.05).