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Table 1 Sensitivity of Bel-7402/ADMS, Bel-7402/ADML and Bel-7402/ADMV cells to multiple chemotherapy drugs.

From: Comparison of the multi-drug resistant human hepatocellular carcinoma cell line Bel-7402/ADM model established by three methods

Drug IC50(mg.L-1, x ¯ ± s) RI
  Bel-7402 Bel-7402/ADMS Bel-7402/ADML Bel-7402/ADMV RIS RIL RIV
ADM 2.09 ± 0.13 26.69 ± 0.46 26.92 ± 0.38 46.93 ± 0.82 12.77 12.88 22.45
CDDP 0.98 ± 0.11 12.92 ± 3.45 13.46 ± 3.00 25.18 ± 3.57 13.18 13.73 25.69
MMC 0.54 ± 0.05 0.57 ± 0.08 0.60 ± 0.08 0.62 ± 0.04 1.06 1.11 1.15
MTX 0.15 ± 0.05 0.17 ± 0.05 0.20 ± 0.06 0.21 ± 0.05 1.13 1.33 1.4
5-FU 119.65 ± 6.46 120.78 ± 4.84 121.60 ± 6.15 123.66 ± 5.00 1.01 1.02 1.03
  1. Note: By least significant difference (LSD) paired-comparison in both ADM and CDDP groups, except Bel-7402/ADML vs. Bel-7402/ADMS (P > 0.05), there is no statistical significance. In other groups of resistant cells, there is a significant difference by paired-comparison. In addition, in MMC, MTX and 5-FU groups, there is no statistical significance by paired-comparison (P > 0.05).
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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