Expression of Slug, Twist, Snail and E-cadherin in human bladder cancer and bankground tissue was determined by immunohistochemistry. Staining of Snail(A), Slug(B), and Twist(C) was found in the cytoplasm as well as in the nucleus of tumor cells. Magnification, ×200. E-cadherin (D)expression was identified in the cell membrane and intensive in the cytoplasm. Magnification, ×200. No expression of Slug in bankground tissue(E), strong of Twist and Snail expression in bankground tissue (F-G).