Expression and clinical significance of multidrug resistance proteins in brain tumors

Table 4 Positive expression of the 5 multidrug resistance proteins in the different grades of brain tumors

Multidrug resistance proteins	Tumor cells			Capillary vessels			Interstitial cells
	H	L	P	H	L	P	H	L	P
n	10	20	-	10	20	-	10	20	-
P-gp	4	3	0.378	6	2	0.027	8	19	0.251
Popo	4	4	0.384	0	0	-	0	0	-
GST	3	2	0.3	0	0	-	8	14	0.682
MRP	0	0	-	0	0	-	2	2	0.584
LRP	0	0	-	0	0	-	2	2	0.584

In tumor cells and interstitial cells, there was no significant difference between the expression of the 5 multidrug resistance proteins (Fisher definite probability methods, P > 0.05) between high grade and low grade tumors. In the capillary vessels, the strong positive expression of P-gp was 60% (6/10) in high grade and 10% (2/20) in low grade tumors. This difference was statistically significant (Fisher definite probability methods, P < 0.05).

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