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Table 1 Distribution of EGFR gene copy number evaluated by CISH according to tumor histotype

From: Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer

Histotype

N° of cases

Disomy

Trisomy

Polysomy

Amplified

ADC

7

1

2

3

1

LCC

8

2

1

4

1

SCC

5

1

3

1

0

mCRC

13

2

4

7

0

Total

33

6

10

15

2

  1. ADC: adenocarcinoma; LCC: large cell carcinoma; SCC: squamous cell carcinoma; mCRC: metastatic colo-rectal cancer; Disomy: 1.6-2.0 balanced gene and chromosome 7; Trisomy: balanced 2.2-3.0 gene and chromosome 7; Polysomy: 3.1-4.4 balanced gene and chromosome 7; Amplified: gene-to-chromosome 7 ratio ≥ 2