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Table 1 Distribution of EGFR gene copy number evaluated by CISH according to tumor histotype

From: Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer

Histotype N° of cases Disomy Trisomy Polysomy Amplified
ADC 7 1 2 3 1
LCC 8 2 1 4 1
SCC 5 1 3 1 0
mCRC 13 2 4 7 0
Total 33 6 10 15 2
  1. ADC: adenocarcinoma; LCC: large cell carcinoma; SCC: squamous cell carcinoma; mCRC: metastatic colo-rectal cancer; Disomy: 1.6-2.0 balanced gene and chromosome 7; Trisomy: balanced 2.2-3.0 gene and chromosome 7; Polysomy: 3.1-4.4 balanced gene and chromosome 7; Amplified: gene-to-chromosome 7 ratio ≥ 2