Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer

Table 3 Comparison between CISH and FISH in 33 cell blocks from lung FNAC

CISH: chromogenic in situ hybridization; FISH: fluorescence in situ hybridization; NA: not amplified, gene-to-chromosome 7 ratio < 2; A: amplified, gene-to-chromosome 7 ratio ≥2; Disomy: 1.6-2.0 balanced gene and chromosome 7; Polysomy: 3.1-4.4 balanced gene and chromosome 7
Concordance 97%; k = 0.78; p < 0.0001; Sensitivity 67%; Specificity 100%; Positive predictive value 100%; Negative predictive value 97%

ISSN: 1756-9966