Identification of sequence polymorphism in the D-Loop region of mitochondrial DNA as a risk factor for hepatocellular carcinoma with distinct etiology

Table 4 Comparison of SNP frequencies with different 489 status among subject groups.

SNPs	Control (n = 38)	HBV-HCC (n = 49)	Alcohol-HCC (n = 11)	P value^d
489T/152T	19 (50.0)^c	13 (26.5)	3 (27.3)	>0.9999
P value		*0.0243*	0.3028
489C/152T	11 (28.9)	18 (36.7)	8 (72.7)	0.0437
P value		0.4447	0.0139
489C/249A	13 (34.2)	19 (38.8)	8 (72.7)	0.0513
P value		0.6614	0.0372
489C/309C	6 (15.8)	12 (24.5)	6 (54.5)	0.0706
P value		0.3204	0.0158
489T/523A	19 (50.0)	11 (22.4)	3 (27.3)	0.7075
P value		*0.0073*	0.3028
489C/523Del	2 (5.3)	6 (12.2)	6 (54.5)	0.0051
P value		0.4571	0.0007
489T/525C	18 (47.4)	10 (20.4)	3 (27.3)	0.6899
P value		*0.0076*	0.3106
489C/525Del	3 (7.9)	6 (12.2)	6 (54.5)	0.0051
P value		0.7256	0.0020

^aHCC vs. control (Number/patient: unpaired T test; SNP-defined haplotypes: Fisher's Exact test, otherwise chi-square analysis to obtain values in italic).
^bMean ± standard deviation.
^cNumber in parenthesis: percentage.
^dHBV-HCC vs. Alcohol-HCC.

ISSN: 1756-9966