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Table 3 EGFR mutations found in the NSCLC samples using a combination of DNA sequencing and ARMS.

From: A comparison of ARMS and DNA sequencing for mutation analysis in clinical biopsy samples

Mutation

No. of mutations

Detected by ARMS*

Detected by sequencing

del E746-A750

9

9

4

del E749-E758insQP

1

ND

1

del L747-P753 ins Q

1*

ND

1

del E749-A753 ins P

1

ND

1

del L747-P753 ins S

1

ND

1

Other deletions

1

ND

1

G719A

1

ND

1

A743S

1

ND

1

L858R

9*

9

4

L861Q

2

ND

2

Total

27

18

17

  1. EGFR-2 kit detecting L858R and del E746-A750 only. Other mutations not detectable by this version of the kit.
  2. *One patient had both an exon 19 deletion and an L858R point mutation.ND, not detectable.