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Table 3 Characterization of NK cell ligands on gastric tumor cells

From: Ex-vivo expanded human NK cells express activating receptors that mediate cytotoxicity of allogeneic and autologous cancer cell lines by direct recognition and antibody directed cellular cytotoxicity

 

Patient 1 (N = 2)

Patient 2 (N = 3)

 

Mean

Range

Mean

Range

Inhibitory ligands

HLA class 1

75%

71%-80%

67%

30%-97%

HLA-E

1%

0%-1%

2%

1%-3%

HLA-G

42%

28%-56%

57%

30%-82%

Activating ligands

PVR

8%

3%-14%

9%

3%-18%

Nectin-2

92%

87%-98%

92%

87%-97%

MIC A/B

2%

1%-2%

1%

0%-1%

ULBP-1

3%

2%-4%

3%

2%-4%

ULBP-2

62%

60%-65%

67%

51%-76%

ULBP-3

3%

3%-4%

3%

2%-4%

Other

    

Fas

36%

21%-50%

95%

88%-99%

EGFR

95%

93%-98%

18%

7%-29%