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Table 3 Characterization of NK cell ligands on gastric tumor cells

From: Ex-vivo expanded human NK cells express activating receptors that mediate cytotoxicity of allogeneic and autologous cancer cell lines by direct recognition and antibody directed cellular cytotoxicity

  Patient 1 (N = 2) Patient 2 (N = 3)
  Mean Range Mean Range
Inhibitory ligands
HLA class 1 75% 71%-80% 67% 30%-97%
HLA-E 1% 0%-1% 2% 1%-3%
HLA-G 42% 28%-56% 57% 30%-82%
Activating ligands
PVR 8% 3%-14% 9% 3%-18%
Nectin-2 92% 87%-98% 92% 87%-97%
MIC A/B 2% 1%-2% 1% 0%-1%
ULBP-1 3% 2%-4% 3% 2%-4%
ULBP-2 62% 60%-65% 67% 51%-76%
ULBP-3 3% 3%-4% 3% 2%-4%
Other     
Fas 36% 21%-50% 95% 88%-99%
EGFR 95% 93%-98% 18% 7%-29%