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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors

Figure 2

LOH analysis in 2.4 Mb region of chromosome 7p. Results from LOH-containing pediatric Wilms (W) and adult renal carcinoma (RCC) samples are aligned with a 7p21.1 to 7p21.2 SNP map. Patient identifiers are shown on the right; RCC denotes adult renal cell carcinoma and W denotes Wilms tumors. Only those patients exhibiting LOH are shown. The 51 SNP markers used in this study are shown along the bottom. They are mapped according to their physical location from 15400000 to 18000000 on chromosome 7p21. The terminal location is at the right; the centrosomal end is on the left. For each patient's row, black boxes indicate regions where all genotyped SNPs show LOH in the tumor samples. Gray blocks indicate regions of uninformative SNPs in between observed regions of LOH. Unmarked areas of each sample indicate informative SNPs where no LOH was observed. The dotted lines highlight the region covered by SOSTDC1. We note that three samples (two Wilms and one RCC) show a large region of LOH that includes either the entire genotyped region (W-733 and W-8188) or a ~1 Mb region including SOSTDC1 (RCC-614). LOH does not appear to center around a particular gene. The genes within this region of interest code for the following proteins: transmembrane protein 195 (TMEM195); mesenchyme homeobox 2 (MEOX2); isoprenoid synthase domain containing (ISPD); sclerostin domain-containing protein (SOSTDC1); ankyrin repeat and MYND domain-containing protein 2 (ANKMY2); basic leucine zipper and W2 domain-containing protein 2 (BZW2); tetraspanin-13 (TSPAN13); anterior gradient protein 2 homolog precursor (AGR2); anterior gradient protein 3 homolog precursor (AGR3); aryl hydrocarbon receptor precursor (AHR); and sorting nexin-13 (SNX13).

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