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Table 1 Results of direct sequencing of SOSTDC1

From: Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors

Sample

Location

Informative SNPs

without LOH

Normal

Tumor

RCC-129

End of Exon 1:

rs35324397

Yes

A/G

G

RCC-614

Beginning of Exon 1:

16,536,670; 16,536,667

between rs10240242 and rs35324397

Yes

G/T, A/G

T, A

RCC-614

Beginning of Exon 1:

16,536,641

between rs10240242 and rs35324397

Yes

C/G

C

RCC-614

End of Exon 1:

rs35324397

Yes

C/G

C

RCC-614

End of Exon 1:

5 bp downstream of rs35324397

Yes

A/G

G

RCC-635

Beginning of Exon 1:

16,536,641

between rs10240242 and rs35324397

Yes

C/G

C

RCC-737

Exon 5:

16,468,252

closest to rs6959246

Yes

G/T

T

W-733

Before Exon 1:

rs7781903

No

C/T

C

W-733

Beginning of Exon 1:

between rs10240242 and rs35324397

No

C/G

G

W-733

Beginning of Exon 2:

rs7801569

No

C/T

C

W-8188

Beginning of Exon 2:

rs7801569

No

C/T

C

W-8197

Exon 5:

16,468,252

closest to rs6959246

No

G/T

T

  1. SNPs found in the direct sequences are summarized here. All other samples sequenced showed no LOH or other mutations. SNP location relative to sequenced exons and chromosome 7 base pair location is provided. The existence of heterozygous SNPs (informative, but with no LOH present) in the sample is shown via yes/no designation. RCC = adult renal carcinoma samples, W = pediatric Wilms tumors.