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Table 1 Results of direct sequencing of SOSTDC1

From: Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors

Sample Location Informative SNPs
without LOH
Normal Tumor
RCC-129 End of Exon 1:
rs35324397
Yes A/G G
RCC-614 Beginning of Exon 1:
16,536,670; 16,536,667
between rs10240242 and rs35324397
Yes G/T, A/G T, A
RCC-614 Beginning of Exon 1:
16,536,641
between rs10240242 and rs35324397
Yes C/G C
RCC-614 End of Exon 1:
rs35324397
Yes C/G C
RCC-614 End of Exon 1:
5 bp downstream of rs35324397
Yes A/G G
RCC-635 Beginning of Exon 1:
16,536,641
between rs10240242 and rs35324397
Yes C/G C
RCC-737 Exon 5:
16,468,252
closest to rs6959246
Yes G/T T
W-733 Before Exon 1:
rs7781903
No C/T C
W-733 Beginning of Exon 1:
between rs10240242 and rs35324397
No C/G G
W-733 Beginning of Exon 2:
rs7801569
No C/T C
W-8188 Beginning of Exon 2:
rs7801569
No C/T C
W-8197 Exon 5:
16,468,252
closest to rs6959246
No G/T T
  1. SNPs found in the direct sequences are summarized here. All other samples sequenced showed no LOH or other mutations. SNP location relative to sequenced exons and chromosome 7 base pair location is provided. The existence of heterozygous SNPs (informative, but with no LOH present) in the sample is shown via yes/no designation. RCC = adult renal carcinoma samples, W = pediatric Wilms tumors.