Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer

Table 2 Comparison of pharmacokinetic parameters of 5-fluorouracil in plasma between administration of S-1 alone and gemcitabine (GEM)+S1

	Cmax (ng/ml)	AUCinf (hXng/ml)	T1/2 (h)	Tmax (h)
Day 3	162 ± 46	853 ± 329	1.96 ± 0.73	3.16 ± 0.81
(S-1 alone)
Day 15	135 ± 56	682 ± 256	2.22 ± 0.84	3.07 ± 0.53
(GEM+S-1)
P-value	0.8644	0.2063	0.604	0.1683

GEM was intravenously given at a dose of 800 mg/m2 S-1 was orally given at a dose of 30 mg/m2.
Cmax, maximum plasma concentration;
AUCinf, area under plasma concentration-time curve from time zero to infnite time; T1/2, elimination half-life; Tmax, the time required to reach Cmax.
Titers were expressed as means ± SD (n = 6). P-values were examined by two-sided paired t-test after log-transformation.

ISSN: 1756-9966