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Table 1 Correlation between biomarkers and primary tumor characteristics

From: Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis

  CXCR4 cytoplasmic expression CXCR4 nuclear expression CCR7 expression EGFR expression
  Low High P Low High P Low High P Low High P
  (n) (n)   (n) (n)   (n) (n)   (n) (n)  
age    .842    .409    .169    .299
<50 43 51   38 56   37 57   49 45  
≥50 47 59   49 57   52 54   63 43  
tumor size    .539    .106    .945    .525
D≤2 27 41   36 32   31 37   38 30  
2<D≤5 50 56   39 67   46 60   62 44  
D>5 13 13   12 14   12 14   12 14  
grade    .068    .985    .786    .030*
I 6 8   6 8   6 8   9 5  
II 59 73   58 74   61 71   81 51  
III 25 29   23 31   22 32   22 32  
stage    .148    .052    .086    .088
I 22 17   23 16   23 16   22 17  
II 61 77   58 80   60 78   82 56  
III 7 13   6 14   5 15   8 12  
IV 0 3   0 3   1 2   0 3  
LN    <.001**    .199    <.001**    .046*
negative 59 41   48 52   59 41   63 37  
positive 31 69   39 61   30 70   49 51  
N    .437    .534    .341    .770
N≤3 11 30   18 23   10 31   21 20  
3<N≤10 11 16   11 16   11 16   14 13  
N>10 9 23   10 22   9 23   14 18  
ER    .256    .117    .319    .087
negative 49 51   49 51   48 52   50 50  
positive 41 59   38 62   41 59   62 38  
PR    .115    .084    .249    .466
negative 51 50   50 51   49 52   54 47  
positive 39 60   37 62   40 59   58 41  
HER2/neu    .039*    .852    .099    .005**
negative 75 78   66 26   73 80   94 59  
positive 15 32   21 87   16 31   18 29  
  1. D represents the diameter of tumor, LN represents lymph node status, N represents the amoumt of lymph node excised, grade means the histological grade, and stage means the clinical stage. *P < 0.05, **P < 0.01