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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein

Figure 1

Effect of ATRA on cell proliferation of GIST-T1, GIST-882 and human normal fibroblast WI-38 cells. GIST-T1, GIST-882 and human normal fibroblast WI-38 cells at a density of 1 × 105 cells/ml were treated with different concentrations of ATRA dissolved in DMSO or with DMSO alone (0 μM ATRA as control) for 3 days. Panel A shows cell growth curve which represents the effect of different concentrations of ATRA. Results were calculated as the percentage of the control values. Panel B shows the effect of ATRA on adherence of GIST-T1 cells at various concentrations of ATRA. Panel C shows cell morphologic change of GIST-T1 cells after 3-day treatment with 180 μM ATRA.

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