Table 2 Differential activity of transcription factorsin two HCC cell lines (SMMC-7721, HCCLM6) with different OPN expression levels (> 2 fold or <0.5-fold change)

Up-regulation

MAZ

3.10

MYC-associated zinc finger protein

E4BP4

2.86

nuclear factor, IL- 3 regulated

c-Myb

2.80

GATA-2

2.74

GATA binding protein 2

TEF1

2.73

activator

PEBP2

2.39

polyoma enhancer binding protein 2

Smad3/4

2.27

MADH3/4

IRF-1/2

2.21

interferon regulatory factor 1/2

PEBP

2.13

polyoma enhancer binding protein

GAG

2.13

amyloid precursor protin (APP) regulator

ADR1

2.10

alcohol dehydrogenase regulatory gene 1

Down-regulation

NF-E2

0.19

nuclear factor (erythroid-derived 2), 45 kDa

EGR

0.21

early growth response

C/EBPα

0.22

CCAAT/enhancer binding protein alpha

E2F-1

0.28

E2F transcription factor 1

CYP1A1

0.30

cytochrome P450-c

HiNF-A

0.31

A nuclear protein

Sp1

0.31

Sp1 transcription factor

E12/E47

0.31

enhancer binding factors E12/E47

PARP

0.34

poly(ADP-ribose) synthetase/polymerase

ELK1

0.34

member of ETS oncogene family

E4F1

0.34

E4F transcription factor 1