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Table 1 In vitro screening in human tumor cell lines

From: 6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis

 

IC50 value (μM)*

Compound

Lymphoma

Leukemia

 

U-937

HL-60

MOLT-4

1a

25.3

15.7

-

1b

37.5

19.3

-

1c

28.4

32.5

-

1d

1.4

0.7

4.2

1e

24.6

26.9

-

1f

32.7

17.6

-

1g

29.2

57.6

-

1 h

36.9

26.0

-

1i

1.0

0.8

6.0

1j

18.6

39.9

-

Doxorubicin

-

-

11.0

5-FU

4.7

266

-

Cis-Platin

3.2

7.0

-

BCNU

12.3

30.5

-

Hydroxyurea

115

204

-