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Table 1 In vitro screening in human tumor cell lines

From: 6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis

  IC50 value (μM)*
Compound Lymphoma Leukemia
  U-937 HL-60 MOLT-4
1a 25.3 15.7 -
1b 37.5 19.3 -
1c 28.4 32.5 -
1d 1.4 0.7 4.2
1e 24.6 26.9 -
1f 32.7 17.6 -
1g 29.2 57.6 -
1 h 36.9 26.0 -
1i 1.0 0.8 6.0
1j 18.6 39.9 -
Doxorubicin - - 11.0
5-FU 4.7 266 -
Cis-Platin 3.2 7.0 -
BCNU 12.3 30.5 -
Hydroxyurea 115 204 -