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Table 3 Somatostatin receptor subtype-binding affinity of somatostatin analogues.

From: Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumours, current aspects and new perspectives

Receptor subtype affinity [IC50, nM]

Compound

SSTR1

SSTR2

SSTR3

SSTR4

SSTR5

SMS-14

2.26

0.23

1.43

1.77

0.88

SMS-28

1.85

0.31

1.3

ND

0.4

Octreotide

1140

0.56

34

7030

7

Lanreotide

2330

0.75

107

2100

5.2

Pasireotide

9.3

1

1.5

>100

0.16

  1. SMS, Somatostatin; ND, not determined.
  2. [Data from Grozinsky-Glasberg S., Endocrine-Related Cancer 2008 Sep;15[3]:701-20].