Table 2 Effect of N-Acetylcystein, DL-buthionin-(S,R)-sulfoximine or z-VAD co-incubation with Taurolidine in different cell lines.
HT29 | Chang Liver | HT1080 | AsPC-1 | BxPC-3 | ||
|---|---|---|---|---|---|---|
NAC+TRD 6 h | Viable: | Ø | Ø | Ø | CoProt | Ø |
Apo/Nec: | Apo⇓ | Ø | Nec⇓ | Nec⇓ | Ø | |
NAC+TRD 24 h | Viable: | CoProt | PaProt. | Del | PaProt | PaProt |
Apo/Nec: | Apo⇓ | Apo⇓ | Apo⇑ Nec⇑ | Nec⇓ Apo⇑ | Nec⇓ | |
BSO alone 6 h | Viable: | Ø | Ø | Ø | Ø | Ø |
Apo/Nec | Ø | Ø | Ø | Ø | Ø | |
BSO+TRD 6 h | Viable: | Ø | Ø | Ø | Ø | Del |
Apo/Nec: | Ø | Ø | Nec⇓ | Nec⇑ Apo⇓ | Nec⇑ | |
BSO alone 24 h | Viable: | Del | Ø | Ø | Ø | Del |
Apo/Nec: | Nec⇑ | Ø | Ø | Ø | Nec⇑ | |
BSO+TRD 24 h | Viable: | Del | Ø | Ø | Del | Del |
Apo/Nec: | Nec⇑ | Ø | Ø | Nec⇑ | Apo⇑ Nec⇓ | |
z-VAD+ TRD 24 h | Viable: | CoProt | PaProt | PaProt | Ø | Ø |
Apo/Nec: | Apo⇓ | Ø | Nec⇓ | Nec⇑ | Nec⇓ |