Figure 1

Effect of TZDs on VEGF-A mRNA expression in lung cancer cell lines. RERF-LC-AI (left panel) and PC-14 (right panel) cells were treated with 0, 10, 50, or 100 μM of troglitazone (upper panel) or ciglitazone (lower panel). The culture medium contained 0.1% DMSO to maintain the same conditions throughout the experiments. After 24 h of treatment, specific mRNA was quantified using real-time PCR. Data were normalized relative to the level of 18S rRNA, and expressed as mean (SD) (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle control.