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Table 1 Relative mRNA expression levels of VEGF-A, its receptors, transcription factor HIF-1α, and transcriptional coactivator PGC-1α.

From: Thiazolidinediones enhance vascular endothelial growth factor expression and induce cell growth inhibition in non-small-cell lung cancer cells

Troglitazone (μM) VEGF-A FLT-1 KDR NRP-1 HIF-1α PGC-1α
RERF-LC-AI (Squamous cell carcinoma) DMSO 1.00 ± 0.28 1.00 ± 0.13 N.D. 1.00 ± 0.03 1.00 ± 0.16 1.00 ± 0.20
  10 1.14 ± 0.08 1.08 ± 0.43   1.00 ± 0.18 1.24 ± 0.31 0.95 ± 0.20
  50 1.39 ± 0.42 0.97 ± 0.48   1.03 ± 0.45 1.27 ± 0.23 0.82 ± 0.05
  100 4.26 ± 0.74 ** 1.23 ± 0.18   5.79 ± 0.48*** 1.35 ± 0.26 0.92 ± 0.10
SK-MES-1 (Squamous cell carcinoma) DMSO 1.00 ± 0.06 N.D. 1.00 ± 0.24 1.00 ± 0.04 1.00 ± 0.23 1.00 ± 0.41
  10 1.21 ± 0.17   1.29 ± 0.26 1.09 ± 0.11 1.40 ± 0.66 1.00 ± 0.26
  50 1.81 ± 0.18**   0.60 ± 0.05 1.07 ± 0.04 3.07 ± 0.32*** 1.09 ± 0.22
  100 3.34 ± 0.16***   0.49 ± 0.15* 1.42 ± 0.06*** 3.13 ± 0.11*** 0.85 ± 0.06
PC-14 (Adenocarcinoma) DMSO 1.00 ± 0.07 N.D. N.D. 1.00 ± 0.05 1.00 ± 0.05 N.D.
  10 1.13 ± 0.12    0.98 ± 0.11 1.29 ± 0.09**  
  50 1.80 ± 0.08    1.29 ± 0.47 1.39 ± 0.08**  
  100 4.18 ± 0.21***    1.68 ± 0.24* 1.35 ± 0.09**  
A549 (Adenocarcinoma) DMSO 1.00 ± 0.05 N.D. N.D. 1.00 ± 0.12 1.00 ± 0.23 1.00 ± 0.10
  10 1.06 ± 0.11    0.89 ± 0.05 1.40 ± 0.66 1.16 ± 0.28
  50 1.90 ± 0.32***    1.35 ± 0.42 3.07 ± 0.32*** 1.95 ± 0.44**
  100 2.10 ± 0.16***    1.04 ± 0.12 3.13 ± 0.11*** 1.36 ± 0.06
  1. Data were normalized relative to the level of 18S rRNA, and expressed as mean (SD) of 3 experiments. *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle control.