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Table 5 Overall frequency and pooled prevalence ratio of mutations affecting the two hot spots of PIK3CA located in Exon 9 and exon 20 in 36 series grouped by cancer type

From: The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type

Tumor Type

nr. series

total cases

Exon 9

Exon 20

Ex20/Ex9

Prevalence Ratio

(95% CI)

P-value

Breast Cancer (histotype not specified)

6

788

101

105

1.0 (0.8 -1.4)

0.7805

Breast Cancer (lobular histotype)

4

99

25

15

0.6 (0.3 -1.1)

0.1178

Breast Cancer (ductal histotype)

5

499

41

64

1.6 (1.1 -2.3)

0.0260

Endometrial Cancer

5

263

7

29

4.1 (1.9 -10.3)

0.0007

Colon Cancer

6

1292

134

80

0.6 (0.5 -0.8)

0.0003

Gastric Cancer

5

602

17

46

2.7 (1.6 -4.9)

0.0005

Head and Neck squamous Cancer

3

175

7

2

0.3 (0.0 -1.2)

0.1182

Glioblastoma

4

203

3

5

1.7 (0.4 -8.1)

0.4842