Figure 4

Growth and apoptosis analysis of tumors xenografts in athymic nude mice. A. Mean body weight and NPC tumor burden treated with LY294002. B. Upper: treatment with LY294002(75 mg/kg); Under: no treatment group. C. Representative areas are shown (× 400 magnification). TUNEL-positive cells in orthotopic tumor xenografts (Lift: no treatment group; Right: treatment with 75 mg/kg LY2940020). D. Apoptosis rate induced by different concentrations of LY294002 in tumors xenografts in athymic nude mice.