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Figure 4 | Journal of Experimental & Clinical Cancer Research

Figure 4

From: The effect of transforming growth factor-β1 on nasopharyngeal carcinoma cells: insensitive to cell growth but functional to TGF-β/Smad pathway

Figure 4

Localization of expression of the TβR-II, Smad2, Smad3, Smad4, Smad7 and phosphorylated Smad2 in CNE2 cells. (A) The TβR-II was located mainly in the cell membrane, and positive staining Smad2, Smad3, Smad4, was found in regions of both cytoplasm and nucleus, while the staining of Smad7 was mainly in the area of nucleus. (B) Phosphorylated Smad2 was undetectable in CNE2 cells without TGF-β1, after stimulation with TGF-β1, phosphorylated Smad2 could be detected in the cytoplasm of CNE2 cells, while Smad7 located originally in nuclear without TGF-β1, and it could be detected in the cytoplasm after stimulation of TGF-β1.

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