|
Adverse event
|
Any grade ≥ 1
|
Grade 1
|
Grade 2
|
Grade 3
|
Grade 4
|
|---|
|
Leucopenia
|
26 (49.1)
|
10 (18.9)
|
11 (20.8)
|
3 (5.7)
|
2 (3.8)
|
|
Neutropenia
|
20 (37.7)
|
6 (11.3)
|
9 (17.0)
|
3 (5.7)
|
2(3.8)
|
|
Thrombocytopenia
|
17 (32.1)
|
11 (20.8)
|
2 (3.8)
|
2 (3.8)
|
2 (3.8)
|
|
Anemia
|
8 (15.1)
|
4 (7.5)
|
4 (7.5)
|
-
|
-
|
|
ALT/AST
|
3 (5.7)
|
3 (5.7)
|
-
|
-
|
-
|
|
Nausea/Vomiting
|
26 (49.1)
|
16 (30.2)
|
9 (17.0)
|
1 (1.9)
|
-
|
|
Diarrhea
|
1 (1.9)
|
-
|
-
|
-
|
1 (1.9)
|
|
Creatinine
|
1 (1.9)
|
-
|
-
|
-
|
1 (1.9)
|
|
Pyrexia
|
5 (9.4)
|
4 (7.5)
|
1 (1.9)
|
-
|
-
|
|
Fatigue
|
10 (18.9)
|
10 (18.9)
|
-
|
-
|
-
|
|
Rash
|
5 (9.4)
|
1 (1.9)
|
3 (5.7)
|
1 (1.9)
|
-
|
|
Inflammation
|
3 (5.7)
|
-
|
3 (5.7)
|
-
|
-
|
- Data are number of patients with rates in brackets
