cluster | number of genes | type of change in gene expression |
---|---|---|
I. Treatment with ATRA and CA; SK-N-BE(2) cell line | ||
I.A | 7 | strong increase especially after treatment with 10 ATRA/52 CA; marked increase noted also after treatment with 1 ATRA alone and all other combinations |
I.B | 14 | marked increase especially after treatment with 1 ATRA/13 CA; the increase noted also after treatment with 1 ATRA alone |
I.C | 18 | marked increase especially after treatment with 1 ATRA and also both combinations of ATRA with CA; 10 ATRA alone or in combinations with CA decreases gene expression |
I.D | 6 | slight increase after treatment with 1 RA; marked decrease after treatment with 10 RA and all combinations |
I.E | 5 | decrease after treatment with 10 ATRA in both combinations with CA |
II. Treatment with ATRA and CA; SH-SY5Y cell line | ||
II.A | 12 | strong increase especially after treatment with 10 ATRA/52 CA; marked increase noted also after treatment with 10 ATRA alone and all other combinations in concentration-dependent manner |
II.B | 58 | marked increase especially after treatment with 1 ATRA in both combinations with CA and also after treatment with 10 ATRA/52 CA; application of ATRA alone showed no influence on gene expression |
II.C | 27 | marked increase after treatment with 1 ATRA in both combinations; application of ATRA alone and 10 ATRA in both combinations showed no influence on gene expression |
II.D | 4 | strong increase after treatment with 10 ATRA/52 CA; application of ATRA alone and all other combinations showed no or minimal influence on gene expression |
III. Treatment with ATRA and CX; SK-N-BE(2) cell line | ||
III.A | 6 | strong increase after treatment with 10 ATRA/10 CX and 1 ATRA/50 CX; slight increase after treatment with 1 ATRA/10 CX; application of ATRA alone showed no or minimal influence on gene expression |
III.B | 6 | marked increase after treatment with ATRA in all combinations with CX; treatment with 1 ATRA alone showed the same effect on gene expression as observable in control cells |
III.C | 22 | strong increase after treatment with ATRA in all combinations with CX; slight increase after treatment with 1 ATRA alone |
III.D | 4 | marked increase after treatment with ATRA in all combinations with CX; decrease after treatment with ATRA alone |
III.E | 60 | strong increase after treatment with 1 ATRA/10 CX; slight increase after treatment with 1 ATRA alone |
IV. Treatment with ATRA and CX; SH-SY5Y cell line | ||
IV.A | 15 | marked increase after treatment with 10 ATRA alone and also in both combinations with CX; application of 1 ATRA alone or in combinations with CX showed no or minimal influence on gene expression |
IV.B | 15 | strong increase after treatment with 1 ATRA/10 CX; slight increase after treatment with 10 ATRA in both combinations with CX |
IV.C | 32 | strong increase after treatment with 10 ATRA/50 CX |
IV.D | 4 | marked increase after treatment with 1 ATRA/10 CX; marked decrease after treatment with all other combinations |