Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study

Table 2 Genes with changed expression detected in particular cell line (SK-N-BE(2) or SH-SY5Y) after combined treatment with ATRA and both inhibitors (CA or CX)

SK-N-BE(2) cell line	AP2M1, ATF4, CCT5, CDK4, COX6C, COX7A2, GDF15, GSK3A, HLA-C, HLA-G, HMGB1, IER3, LONP1, MAP2K2, NQO1, PRKAR1A, RET, RHOC, SIVA1, SOD1, TBRG4, TIMP1, TP53I3, TUFM, XRCC5, XRCC6
SH-SY5Y cell line	ANXA5, AP2M1, ATF4, ATP5B, ATP5O, BLMH, CCT5, CDKN1A, CLNS1A, COX6C, COX7A2, GTF2I, HLA-C, HLA-G, KPNA2, LAMB1, LONP1, MCM2, NINJ1, NME1, NME2, PHB, PKM2, PPARD, PRDX4, PTMA, RAP1A, RARA, RB1, RBBP4, RET, RHOC, SLC20A1, SMO, SND1, SNRPB2, TK1, TNFRST10B, TSG101, TUFM, UBC, UBE2L6, VDAC1, XRCC1, XRCC5, XRCC6

ATRA was applied in concentrations of 1 or 10 μM (1 ATRA, 10 ATRA); CA in concentrations of 13 and 52 μM (13 CA, 52 CA), and CX in concentrations of 10 and 50 μM (10 CX, 50 CX). The same genes influenced in both cell lines are underlined.

ISSN: 1756-9966