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Figure 3 | Journal of Experimental & Clinical Cancer Research

Figure 3

From: Potent anti-tumor activity of telomerase-dependent and HSV-TK armed oncolytic adenovirus for non-small cell lung cancer in vitro and in vivo

Figure 3

GCV enhanced inhibition on tumor growth in vitro and in vivo. A. GCV enhanced Ad.hTERT-E1A-TK tumor killing effect in vitro. NCIH460 tumor cells were infected with 10 MOI of Ad.hTERT-E1A-TK and then exposed to different concentration of GCV for 5 days. The surviving cells were quantified with CCK-8 assay and plotted. B. Ad.hTERT-E1A-TK/GCV suppressed tumor growth in vivo. NCIH460 xenograft tumors in nude mice were treated by Ad.null, PBS plus GCV, Ad.hTERT-E1A-TK alone or Ad.hTERT-E1A-TK plus GCV. Tumor sizes were measured twice a week using calipers and tumor volumes were plotted. C. Tumor weight at the end of the study. On day 28 post treatment, all animals were sacrificed and the tumors were removed and weighted. The data represent the mean ± SD from at least 7 animals per group.

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