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Table 1 Correlation between methylation of DDIT3 gene and the clinical characteristics of CML patients.

From: Methylation status of DDIT3 gene in Chronic Myeloid Leukemia

 

Status of DDIT3 methylation

Patient's parameters

Patients with methylated DDIT3

(n = 35)

Patients with unmethelated DDIT3

(n = 18)

Total

(n = 53)

P value

Ages (yr) 1

48 (21-73)

40 (17-83)

45 (17-83)

0.225

Sex (male/female)

28/7

10/8

38/15

0.106

WBC (×109/L) 1

38.0 (2.2-178.6)

161.8 (4.1-235.2)

75.6 (2.2-235.2)

0.007

Hemoglobin (g/dL)1

9.9 (4.9-14.8)

9.3 (5.2-14.3)

9.5 (4.9-14.8)

0.963

Plateletcounts (×109/L) 1

264 (20-1494)

263 (24-870)

264 (20-1494)

0.844

Cytogenetics

   

0.542

   t(9;22)

26 (63%)

15 (37%)

41

 

   variant t(9;22)

2 (100%)

0 (0%)

2

 

   t(9;22) with additional alteration

7 (70%)

3 (30%)

10

 

Staging

   

0.256

   CP

24 (68%)

11 (32%)

35

 

   AP

3 (100%)

0 (0%)

3

 

   BC

8 (53%)

7 (47%)

15

 

bcr/abl transcript

4.82 (0.28-877.94)

3.37 (0.26-221.77)

3.96 (0.26-877.94)

0.583

DDIT3 transcript

2.13 (0.05-65.32)

3.92 (0.12-126.04)

3.28 (0.05-126.04)

0.152

  1. WBC, white blood cells; CP, chronic phase; AP, accelerated phase; BC, blast crisis. 1 Median (range).