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Table 1 Correlation between methylation of DDIT3 gene and the clinical characteristics of CML patients.

From: Methylation status of DDIT3 gene in Chronic Myeloid Leukemia

  Status of DDIT3 methylation
Patient's parameters Patients with methylated DDIT3
(n = 35)
Patients with unmethelated DDIT3
(n = 18)
Total
(n = 53)
P value
Ages (yr) 1 48 (21-73) 40 (17-83) 45 (17-83) 0.225
Sex (male/female) 28/7 10/8 38/15 0.106
WBC (×109/L) 1 38.0 (2.2-178.6) 161.8 (4.1-235.2) 75.6 (2.2-235.2) 0.007
Hemoglobin (g/dL)1 9.9 (4.9-14.8) 9.3 (5.2-14.3) 9.5 (4.9-14.8) 0.963
Plateletcounts (×109/L) 1 264 (20-1494) 263 (24-870) 264 (20-1494) 0.844
Cytogenetics     0.542
   t(9;22) 26 (63%) 15 (37%) 41  
   variant t(9;22) 2 (100%) 0 (0%) 2  
   t(9;22) with additional alteration 7 (70%) 3 (30%) 10  
Staging     0.256
   CP 24 (68%) 11 (32%) 35  
   AP 3 (100%) 0 (0%) 3  
   BC 8 (53%) 7 (47%) 15  
bcr/abl transcript 4.82 (0.28-877.94) 3.37 (0.26-221.77) 3.96 (0.26-877.94) 0.583
DDIT3 transcript 2.13 (0.05-65.32) 3.92 (0.12-126.04) 3.28 (0.05-126.04) 0.152
  1. WBC, white blood cells; CP, chronic phase; AP, accelerated phase; BC, blast crisis. 1 Median (range).