Antitumor effect of VEGF silencing plus DDP on A549 cells in vivo. Tumor growth curves. Each point in the curves represents the mean ± SD (n = 5 tumors). The therapy started on day 7 when the tumors reached a volume of ~50 mm3. The combination of VEGF silencing plus DDP enhanced the inhibition of tumor growth, #P < 0.05 versus 5% GS, *P0.05 versus pshVEGF or DDP, **P < 0.01 versus 5% GS. B) Weight of the tumors. Each bar represents the mean ± SD (n = 5 tumors). *P < 0.05 versus pshVEGF or DDP. Mean weights of the tumors are 0.510 g, 0.490 g, 0.242 g, 0.228 g and 0.110 g, for the 5% GS group, the pshHK group, the pshVEGF group, the DDP group and the pshVEGF plus DDP group, respectively.