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Table 1 Differentially expressed candidate imprinted genes, oncogenes and tumor suppressing genes identified by MAS5.0, Array2BIO and BGX methods

From: Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer

Gene symbol Description Genbank Biological process Biological function
Imprinted gene
Dcn Decorin AV321547 ---- protein binding
Igf2 Insulin like growth factor 2 NM010514 regulation of cell cycle; cell proliferation receptor binding; hormone activity; protein binding; growth factor activity
Mest Mesoderm specific transcript AW555393 Proteolysis Catalytic activity; aminopeptidase activity
Ndn Necdin BB074430 Regulation of cell growth; nerve growth factor receptor signaling pathway; transcription; neuron migration DNA binding; protein binding; gamma-tubulin binding
Peg3 Paternally expressed 3 BB305002 apoptosis Nucleic acid binding; metal ion binding
Oncogenes or tumor suppressor genes
Bcl11a B-cell CLL/lymphoma 11A BF731393 transcription; B cell and T cell differentiation nucleic acid binding; zinc ion binding; transcription co-repressor activity
Ccnd1 cyclin D1 BB452046 Regulation of cell cycle; protein amino acid phosphorylation; fat cell differentiation; cell division protein kinase activity; protein binding
Cdh11 Cadherin 11 BG072720 Cell adhesion Calcium ion binding; protein binding
Egfr Epidermal growth factor receptor BB409522 Cell morphogenesis; signal transduction; cell proliferation; regulation of cell migration; cell adhesion; regulation of peptidyl-tyrosine phosphorylation Nucleotide binding; kinase activity; iron ion binding; ATP binding; protein binding; signal transducer activity; receptor activity; transferase activity; actin filament binding
Fcgr2b Fc receptor, IgG, low affinity IIb BB530063 Negative regulation of type I hypersensitivity; immune response; signal transduction; regulation of B cell proliferation; mast cell activation; regulation of phagocytosis Receptor activity; protein binding; IgG binding
Gpc3 Gypican 3 BM198842 Ureteric bud branching; regulation of cell proliferation; regulation of BMP signaling pathway; regulation of growth GPI anchor binding
Vav3 Vav 3 oncogene BM224051 Vesicle fusion; signal transduction; regulation of cell adhesion; cell migration; intracellular signaling cascade; cell projection biogenesis; regulation of PI3 kinase activity; integrin-mediated signaling pathway diacylglycerol binding; EGFR binding; metal ion binding; exchange factor activity
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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