Table 1 Differentially expressed candidate imprinted genes, oncogenes and tumor suppressing genes identified by MAS5.0, Array2BIO and BGX methods
Gene symbol | Description | Genbank | Biological process | Biological function |
|---|---|---|---|---|
Imprinted gene | ||||
Dcn | Decorin | AV321547 | ---- | protein binding |
Igf2 | Insulin like growth factor 2 | NM010514 | regulation of cell cycle; cell proliferation | receptor binding; hormone activity; protein binding; growth factor activity |
Mest | Mesoderm specific transcript | AW555393 | Proteolysis | Catalytic activity; aminopeptidase activity |
Ndn | Necdin | BB074430 | Regulation of cell growth; nerve growth factor receptor signaling pathway; transcription; neuron migration | DNA binding; protein binding; gamma-tubulin binding |
Peg3 | Paternally expressed 3 | BB305002 | apoptosis | Nucleic acid binding; metal ion binding |
Oncogenes or tumor suppressor genes | ||||
Bcl11a | B-cell CLL/lymphoma 11A | BF731393 | transcription; B cell and T cell differentiation | nucleic acid binding; zinc ion binding; transcription co-repressor activity |
Ccnd1 | cyclin D1 | BB452046 | Regulation of cell cycle; protein amino acid phosphorylation; fat cell differentiation; cell division | protein kinase activity; protein binding |
Cdh11 | Cadherin 11 | BG072720 | Cell adhesion | Calcium ion binding; protein binding |
Egfr | Epidermal growth factor receptor | BB409522 | Cell morphogenesis; signal transduction; cell proliferation; regulation of cell migration; cell adhesion; regulation of peptidyl-tyrosine phosphorylation | Nucleotide binding; kinase activity; iron ion binding; ATP binding; protein binding; signal transducer activity; receptor activity; transferase activity; actin filament binding |
Fcgr2b | Fc receptor, IgG, low affinity IIb | BB530063 | Negative regulation of type I hypersensitivity; immune response; signal transduction; regulation of B cell proliferation; mast cell activation; regulation of phagocytosis | Receptor activity; protein binding; IgG binding |
Gpc3 | Gypican 3 | BM198842 | Ureteric bud branching; regulation of cell proliferation; regulation of BMP signaling pathway; regulation of growth | GPI anchor binding |
Vav3 | Vav 3 oncogene | BM224051 | Vesicle fusion; signal transduction; regulation of cell adhesion; cell migration; intracellular signaling cascade; cell projection biogenesis; regulation of PI3 kinase activity; integrin-mediated signaling pathway | diacylglycerol binding; EGFR binding; metal ion binding; exchange factor activity |