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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: Comparison of the inhibitory effects of three transcriptional variants of CDKN2A in human lung cancer cell line A549

Figure 1

The three transcriptional variants of CDKN2A. The CDKN2A gene located at 9p21 generates three transcriptional variants at transcription: p16INK4a, p14ARF and p12. p16INK4a utilizes exon1α, and p14ARF utilizes exon 1β which is about 20 kb upstream of exon 1α. p16INK4a and p14ARF share common exon 2 and exon 3 but use different reading frames. p12 uses an alternative splice donor site within intron1 of p16INK4a.

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