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Table 2 Sequential changes in expression of individual miRNAs that are differentially expressed between the cell line groups

From: MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs

miRNA

SCLC

NSCLC

HBEC

SCLC NSCLC

SCLC HBEC

NSCLC HBEC

p SCLC NSCLC

p SCLC HBEC

p NSCLC HBEC

pJT

Location

Over-expressed in SCLC cell lines

miR-338

0.47 ± 0.16

0.08 ± 0.04

0.01 ± 0.00

5.71

47.33

8.29

1.62E-03

8.08E-03

2.38E-01

1.99E-05

17q25.3

miR-101

2.46 ± 1.10

0.52 ± 0.25

0.25 ± 0.08

4.72

9.72

2.06

5.22E-03

3.50E-02

4.20E-01

6.41E-05

1p31.3,9p24.1

miR-98

1.79 ± 0.86

0.51 ± 0.27

0.62 ± 0.11

3.52

2.91

0.83

1.56E-02

1.12E-01

7.49E-01

8.96E-03

Xp11.22

miR-106b

0.47 ± 0.20

0.15 ± 0.08

0.07 ± 0.01

3.26

6.78

2.08

1.03E-02

3.41E-02

4.20E-01

3.31E-05

7q22.1

miR-17-5p

1.07 ± 0.57

0.33 ± 0.19

0.29 ± 0.07

3.25

3.72

1.15

2.95E-02

1.12E-01

8.56E-01

9.49E-04

13q31.3

miR-106a

1.26 ± 0.59

0.41 ± 0.23

0.31 ± 0.05

3.10

4.06

1.31

1.96E-02

7.11E-02

7.39E-01

6.25E-04

Xq26.2

miR-96

0.73 ± 0.28

0.26 ± 0.10

0.12 ± 0.05

2.77

6.24

2.25

1.03E-02

3.14E-02

3.36E-01

4.62E-05

7q32.2

miR-15a

0.45 ± 0.15

0.17 ± 0.04

0.18 ± 0.08

2.63

2.55

0.97

5.12E-03

5.48E-02

9.39E-01

3.49E-03

13q14.3

miR-92

0.44 ± 0.17

0.17 ± 0.08

0.15 ± 0.04

2.54

2.96

1.16

1.33E-02

5.48E-02

7.91E-01

5.42E-04

Xq26.2

miR-326

0.49 ± 0.20

0.20 ± 0.11

0.05 ± 0.01

2.49

10.45

4.19

2.45E-02

2.71E-02

3.36E-01

1.04E-04

11q13.4

miR-1

0.09 ± 0.03

0.04 ± 0.03

0.01 ± 0.01

2.40

6.42

2.68

3.92E-02

2.71E-02

5.04E-01

1.24E-03

20q13.33,18q11.2

miR-15b

0.63 ± 0.24

0.26 ± 0.09

0.23 ± 0.10

2.39

2.78

1.17

1.56E-02

7.07E-02

7.75E-01

2.72E-03

3q26.1

miR-195

2.74 ± 1.23

1.19 ± 0.45

0.60 ± 0.06

2.30

4.55

1.98

3.51E-02

5.48E-02

3.36E-01

4.06E-04

17p13.1

miR-103

0.91 ± 0.26

0.41 ± 0.11

0.29 ± 0.07

2.23

3.16

1.42

5.12E-03

1.99E-02

4.20E-01

7.54E-05

5q35.1,20p13

miR-135

0.28 ± 0.12

0.13 ± 0.03

0.08 ± 0.02

2.19

3.41

1.56

2.95E-02

6.50E-02

3.36E-01

2.25E-04

3p21.1,12q23.1

miR-301

0.74 ± 0.28

0.35 ± 0.44

0.05 ± 0.02

2.12

15.95

7.53

1.14E-01

1.68E-02

5.04E-01

2.72E-03

17q22,22q11.21

miR-328

0.76 ± 0.31

0.36 ± 0.19

0.04 ± 0.03

2.12

19.06

9.00

4.42E-02

2.24E-02

2.38E-01

1.42E-04

16q22.1

miR-93

0.94 ± 0.38

0.45 ± 0.09

0.42 ± 0.13

2.07

2.23

1.07

2.95E-02

1.12E-01

7.94E-01

8.27E-04

7q22.1

miR-16

1.04 ± 0.40

0.51 ± 0.15

0.33 ± 0.10

2.03

3.14

1.55

2.95E-02

5.48E-02

4.20E-01

5.42E-04

13q14.3,3q26.1

miR-324-5p

0.43 ± 0.16

0.22 ± 0.22

0.09 ± 0.03

1.95

4.80

2.46

1.14E-01

3.18E-02

5.93E-01

1.24E-03

17p13.1

miR-107

0.71 ± 0.13

0.38 ± 0.13

0.27 ± 0.09

1.86

2.62

1.41

4.74E-03

4.78E-03

4.64E-01

1.66E-04

10q23.31

miR-149

0.24 ± 0.08

0.15 ± 0.12

0.07 ± 0.03

1.56

3.58

2.29

2.12E-01

3.18E-02

4.99E-01

5.02E-03

2q37.3

miR-181c

0.39 ± 0.12

0.25 ± 0.12

0.13 ± 0.07

1.52

2.91

1.91

1.14E-01

3.20E-02

4.26E-01

4.45E-03

19p13.12

miR-148b

0.24 ± 0.10

0.17 ± 0.11

0.06 ± 0.04

1.39

4.24

3.05

3.38E-01

4.69E-02

4.20E-01

5.00E-02

12q13.13

miR-142-3p

0.13 ± 0.05

0.10 ± 0.07

0.03 ± 0.02

1.31

4.03

3.09

4.11E-01

4.46E-02

4.20E-01

1.72E-02

17q22

miR-30c

2.97 ± 0.87

2.47 ± 1.34

1.12 ± 0.09

1.20

2.65

2.20

4.72E-01

3.18E-02

4.20E-01

5.00E-02

1p34.2,6q13

Under-expressed in SCLC cell lines

miR-199a*

0.16 ± 0.11

0.28 ± 0.28

0.74 ± 0.18

0.56

0.21

0.37

3.72E-01

1.43E-03

2.73E-01

2.11E-02

19p13.2,1q24.3

miR-27a

0.31 ± 0.23

0.74 ± 0.27

0.90 ± 0.10

0.42

0.35

0.83

2.73E-02

1.86E-02

6.07E-01

1.42E-03

19p13.12

miR-23b

1.86 ± 0.79

5.29 ± 1.55

5.89 ± 0.65

0.35

0.32

0.90

1.99E-03

4.21E-04

7.49E-01

1.93E-04

9q22.32

miR-222

0.47 ± 0.46

1.33 ± 1.07

2.40 ± 0.67

0.35

0.19

0.55

1.14E-01

3.23E-03

4.26E-01

1.09E-03

Xp11.3

miR-221

0.77 ± 0.83

2.19 ± 1.44

3.51 ± 1.17

0.35

0.22

0.62

9.69E-02

1.10E-02

4.64E-01

6.25E-04

Xp11.3

miR-99a

0.28 ± 0.19

0.85 ± 0.70

0.93 ± 0.20

0.33

0.30

0.91

1.03E-01

5.64E-03

9.25E-01

8.00E-03

21q21.1

miR-24

0.62 ± 0.39

1.93 ± 0.70

2.05 ± 0.12

0.32

0.30

0.94

5.12E-03

2.80E-03

8.76E-01

8.27E-04

9q22.32,19p13.12

miR-29c

0.56 ± 0.20

1.97 ± 1.13

1.59 ± 0.71

0.29

0.36

1.24

1.75E-02

1.68E-02

7.86E-01

1.25E-02

1q32.2

miR-23a

1.19 ± 0.74

4.32 ± 1.83

5.76 ± 0.96

0.27

0.21

0.75

5.12E-03

2.50E-04

4.97E-01

4.70E-04

19p13.12

miR-205

0.45 ± 0.15

1.86 ± 3.04

18.38 ± 4.63

0.24

0.02

0.10

3.03E-01

9.67E-06

9.08E-03

1.79E-01

1q32.2

miR-29b

0.72 ± 0.33

3.07 ± 1.49

2.31 ± 1.38

0.23

0.31

1.33

5.22E-03

3.18E-02

7.14E-01

8.00E-03

7q32.3,1q32.2

miR-29a

0.75 ± 0.29

4.08 ± 2.53

3.73 ± 1.63

0.18

0.20

1.09

1.27E-02

3.23E-03

9.07E-01

6.36E-03

7q32.3

miR-22

0.05 ± 0.02

0.33 ± 0.07

0.24 ± 0.12

0.16

0.22

1.39

3.55E-06

5.64E-03

4.26E-01

1.85E-03

17p13.3

miR-21

4.35 ± 6.37

27.93 ± 10.26

11.01 ± 4.60

0.16

0.39

2.54

1.99E-03

2.23E-01

2.73E-01

1.91E-02

17q23.1

miR-31

0.04 ± 0.06

0.64 ± 0.39

5.65 ± 0.96

0.07

0.01

0.11

5.22E-03

3.85E-07

2.34E-04

2.25E-04

9p21.3

  1. Shown are the mean expression level of each miRNA in SCLC, NSCLC, and HBEC cell lines, p values from two-sided t-tests comparing expression for each miRNA between the three groups, corrected for multiple comparisons using the Benjamini and Hochberg FDR method [27], and p values from the Jonckheere-Terpstra test for ordered alternatives (pJT). The last column contains the chromosomal location.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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