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Table 2 Radiobiological equivalence of schedule used in this study.

From: Accelerated hypofractionated radiotherapy as adjuvant regimen after conserving surgery for early breast cancer: interim report of toxicity after a minimum follow up of 3 years

Treatment

 

Breast

Tumor bed

Schedule

d(Gy) Ă— (n. fr)

3.4 Ă— 10

3.4 Ă— 10 plus 8 Ă— 1

 

Total physical dose (Gy)

34

42

 

Treatment time (days)

12

19

Normal tissue - late effect

Lung (α/β = 3 Gy)

NTD2 (Gy)

43.5

61.1

 

Acceleration (days) * Dprolif

18 * 0.2

24 * 0.2

 

NTDT (Gy)

47.1

65.9

Normal breast (α/β = 3.4 Gy)

NTD2 (Gy)

42.8

59.7

 

Acceleration (days) * Dprolif

17 * 0.2

21 * 0.2

 

NTDT (Gy)

46.2

63.9

Tumor

Breast Tumor (α/β = 4.6 Gy)

NTD2 (Gy)

41.2

56.5

 

Acceleration (days) * Dprolif

17 * 0.7

19 * 0.7

 

NTDT (Gy)

53.1

69.8

Cancer cells (α/β = 10 Gy)

NTD2 (Gy)

38

50

 

Acceleration (days) * Dprolif

13 * 0.7

14 * 0.7

 

NTDT (Gy)

47.1

59.8

  1. Abbreviations: NTD2 is the normalized total dose at 2 Gy fraction, NTDT is the normalized total dose at 2 Gy fraction corrected for time acceleration (see text). Acceleration indicates the difference (t -T) respect to the conventional treatment. Dprolif is the dose recovered per day due to proliferation, to compensate for rapid cell repopulation.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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