Figure 2

The presence of ROS is an important factor in determining sensitivity to adaphostin (ADA). (A) Dose response curves of NCI-H522 after treatment with ADA either alone or in combination with 25 mM n-acetyl cysteine (NAC) or 100 μM desferrioxamine (DFX). ADA sensitivity was attenuated by NAC, but not DFX (n = 3; +/- SD). (B) Dose response curves of Jurkat after treatment with ADA either alone or in combination with 25 mM NAC or 100 μM DFX. ADA sensitivity was attenuated by NAC and DFX (n = 3; +/- SD).