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Table 4 Injection of pGL3-basic- hTERTp-TK- EGFP- CMV/GCV inhibited tumor development in vivo

From: Targeted gene therapy of nasopharyngeal cancer in vitro and in vivo by enhanced thymidine kinase expression driven by human TERT promoter and CMV enhancer

Sample

Animals

Tumor volume at day 39 (cm3)

Tumor weight at day 39 (g)

Inhibition rate

Blank

5

6.23 ± 0.04

2.68 ± 0.02

/

Non-enhanced group

5

3.51 ± 0.02

1.51 ± 0.01

43.68%*

Enhanced group/GCV

5

2.72 ± 0.02

1.17 ± 0.01

56.34%*

Enhanced group

5

5.80 ± 0.13

2.51 ± 0.05

6.48%*

GCV group

5

5.98 ± 0.09

2.56 ± 0.09

4.32%*

Lipofectamine group

5

5.83 ± 0.14

2.51 ± 0.02

6.41%*

  1. Data are expressed as mean ± standard deviation from three experiments. * indicates p < 0.0001 compared with the other group.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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