Skip to main content

Table 3 Comparison of toxicities between wild type and variant allele groups for VEGFR2 SNPs

From: Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib

Toxicity grade ≥2
N (%*)
VEGFR2 H472Q VEGFR2 V297I
  wt allele var allele p-value Wt allele var allele p-value
HT 22 (21.4) 26 (38.8) 0.0154 38 (29.0) 12 (30.8) 0.84
HFSR 16 (15.5) 22 (32.8) 0.0136 28 (21.4) 10 (25.6) 0.66
Rash:desquamation 17 (25.0) 13 (28.9) 0.67 23 (27.7) 9 (30.0) 0.82
Diarrhea 14 (20.6) 7 (15.6) 0.62 19 (22.9) 3 (10.0) 0.18
Fatigue 12 (17.7) 6 (13.3) 0.61 14 (16.9) 4 (13.3) 0.78
  1. *% of total patients in that group,p-values are based on Fisher's exact test. wt: wild-type, var: variant.