Figure 1
From: Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors
Effect of treatment with motesanib or vehicle on hair depigmentation, a surrogate marker of Kit activity [16], in female C57B6 mice. Anesthetized animals were depilated and immediately treated with either vehicle (water; left panels) or motesanib 75 mg/kg BID (right panels) for 21 days. On day 21, hair depigmentation was assessed. Depilation was repeated on day 28 and hair depigmentation was again assessed on day 35. Representative images from each treatment group for the day-21 and day-35 time points are shown. BID = twice daily.