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Table 1 Cyclophilin A in human cancers

From: Current implications of cyclophilins in human cancers

Cancer type

Functions and implications of CypA in cancers


Lung cancer

The first identification of CypA overexpression in lung cancer

Campa et al., Cancer Res. (2003)


Potential role of CypA in early neoplastic transformation and as a biomarker

Howard et al., Lung Cancer (2004)


Regulation of cancer growth, angiogenesisa and apoptosis through CypA knockdown and overexpression

Howard et al., Cancer Res. (2005)


Role of exogenous CypA in increased H446 cell growth through ERK1/2 pathway activation

Yang et al., BBRC (2007)

Pancreatic cancer

Identification of CypA as a decreased factor by 5-aza-2-deoxycytidine

Cecconi et al., Eletrophoresis (2003)


Involvement of increased CypA in pancreatic carcinogenesis

Shen et al., Cancer Res. (2004)


Effect on the gene expression of several key molecules including NRPs, VEGF, and VEGFRs

Li et al., Am J Surg (2005)


Stimulation of cancer cell proliferation by increased CypA through CD 147 signaling

Li et al., Cancer Res (2006)


Association of increased CypA with tumor invasion, metastasis, and resistance to therapy

Mikuriya et al., Int J Oncol (2007)

Hepatocellular carcinoma

Regulation of cancer cell proliferation and increase of hepatocarcinoma formation by interaction of increased CypA with calcineurin

Corton et al., Cancer Let (1998)


Identification as a useful HCC marker in tumor tissues

Lim et al., BBRC (2002)

Breast cancer

Assessment of CypA down-regulation through proteomics in melphalan-resistant and -susceptible MCF-7 cell lines

Hathout et al., J proteomic Res (2002)


Role of CypA in cancer cell progression and regulation of JAK2

Zheng et al., Cancer Res (2008)

Colorectal Cancer

Identification of association of CypA with tumor development and tumor progression through protein profiling

Melle et al., Int J Mol Med (2005)


Role of CypA in COX-2-independent chemopreventive effect by celecoxib

Lou et al., Cancer Epidemiol (2006)


Upregualtion of CypA among5-fluorouracil (5-FU) response proteins for CRC chemotherapy

Wong et al., Oncol Rep (2008)

Squamous cell carcinoma

Involvement in oncogenesis in SCC

Chen et al., Proteomics (2004)


Possible role as a malignant transformation-related protein in ESCC

Qi et al., J Cell Biochem (2008)


High level expression in primary and metastatic melanoma

Al-Ghoul et al., J Proteome Res (2008)

Prostate cancer

Preventing hypoxia- and cisplatin-induced apoptosis

Choi et al., Cancer res (2007)

Glioblastoma multiforme

Increasing expression of CypA in human glioblastoma multiforme

Han et al., Oncol Rep (2010)