Cancer type | Functions and implications of CypA in cancers | Contributers |
---|---|---|
Lung cancer | The first identification of CypA overexpression in lung cancer | Campa et al., Cancer Res. (2003) |
 | Potential role of CypA in early neoplastic transformation and as a biomarker | Howard et al., Lung Cancer (2004) |
 | Regulation of cancer growth, angiogenesisa and apoptosis through CypA knockdown and overexpression | Howard et al., Cancer Res. (2005) |
 | Role of exogenous CypA in increased H446 cell growth through ERK1/2 pathway activation | Yang et al., BBRC (2007) |
Pancreatic cancer | Identification of CypA as a decreased factor by 5-aza-2-deoxycytidine | Cecconi et al., Eletrophoresis (2003) |
 | Involvement of increased CypA in pancreatic carcinogenesis | Shen et al., Cancer Res. (2004) |
 | Effect on the gene expression of several key molecules including NRPs, VEGF, and VEGFRs | Li et al., Am J Surg (2005) |
 | Stimulation of cancer cell proliferation by increased CypA through CD 147 signaling | Li et al., Cancer Res (2006) |
 | Association of increased CypA with tumor invasion, metastasis, and resistance to therapy | Mikuriya et al., Int J Oncol (2007) |
Hepatocellular carcinoma | Regulation of cancer cell proliferation and increase of hepatocarcinoma formation by interaction of increased CypA with calcineurin | Corton et al., Cancer Let (1998) |
 | Identification as a useful HCC marker in tumor tissues | Lim et al., BBRC (2002) |
Breast cancer | Assessment of CypA down-regulation through proteomics in melphalan-resistant and -susceptible MCF-7 cell lines | Hathout et al., J proteomic Res (2002) |
 | Role of CypA in cancer cell progression and regulation of JAK2 | Zheng et al., Cancer Res (2008) |
Colorectal Cancer | Identification of association of CypA with tumor development and tumor progression through protein profiling | Melle et al., Int J Mol Med (2005) |
 | Role of CypA in COX-2-independent chemopreventive effect by celecoxib | Lou et al., Cancer Epidemiol (2006) |
 | Upregualtion of CypA among5-fluorouracil (5-FU) response proteins for CRC chemotherapy | Wong et al., Oncol Rep (2008) |
Squamous cell carcinoma | Involvement in oncogenesis in SCC | Chen et al., Proteomics (2004) |
 | Possible role as a malignant transformation-related protein in ESCC | Qi et al., J Cell Biochem (2008) |
Melanoma | High level expression in primary and metastatic melanoma | Al-Ghoul et al., J Proteome Res (2008) |
Prostate cancer | Preventing hypoxia- and cisplatin-induced apoptosis | Choi et al., Cancer res (2007) |
Glioblastoma multiforme | Increasing expression of CypA in human glioblastoma multiforme | Han et al., Oncol Rep (2010) |